| Autor: |
Chen, Ru-Yi, Ding, Li-Jian, Liu, Yan-Jun, Shi, Jin-Jin, Yu, Jing, Li, Chang-Yun, Lu, Jian-Fei, Yang, Guan-Jun, Chen, Jiong |
| Zdroj: |
Marine Drugs; Oct2024, Vol. 22 Issue 10, p459, 18p |
| Abstrakt: |
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high mortality and drug resistance and no targeted drug available at present. Compound 4, a staurosporine alkaloid derived from Streptomyces sp. NBU3142 in a marine sponge, exhibits potent anti-TNBC activity. This research investigated its impact on MDA-MB-231 cells and their drug-resistant variants. The findings highlighted that compound 4 inhibits breast cancer cell migration, induces apoptosis, arrests the cell cycle, and promotes cellular senescence in both regular and paclitaxel-resistant MDA-MB-231 cells. Additionally, this study identified mitogen-activated protein kinase kinase kinase 11 (MAP3K11) as a target of compound 4, implicating its role in breast tumorigenesis by affecting cell proliferation, migration, and cell cycle progression. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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