First Detection and Characterization of Smacovirus in the Human Vagina in Two Sequential Samples over a Twelve-Day Interval.

Autor: da Costa, Antonio Charlys, Tozetto-Mendoza, Tania Regina, Foro Ramos, Endrya do Socorro, Bortoletto, Pietro, Ferreira, Noely Evangelista, Honorato, Layla, Garcia Barbosa, Erick Matheus, Paião, Heuder Gustavo Oliveira, de Souza, Amanda Fernandes, Linhares, Iara M., Spandorfer, Steven D., Leal, Elcio, Mendes-Correa, Maria Cassia, Witkin, Steven S.
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Zdroj: Viruses (1999-4915); Oct2024, Vol. 16 Issue 10, p1545, 6p
Abstrakt: Background: Smacovirus is a CRESS-DNA virus identified almost exclusively in transient fecal samples from various vertebrate species. Objective: We evaluated human vaginal samples for the presence and maintenance of Smacovirus. Methods: Viral metagenomics analysis was performed on vaginal samples collected from 28 apparently healthy women in New York City, USA. Twenty-one of the women provided duplicate samples over a 12–21-day interval. Results: Phylogenetic analysis identified two samples from the same individual, collected over a twelve-day interval, that were positive for the complete Smacovirus genome. All detected sequence contigs belonged to a single variant of CRESS-DNA. Conclusions: The continuous presence of Smacovirus in the human vagina over a twelve-day period was identified. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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