| Autor: |
Qian, Yongbing, Hong, Xiaoning, Yu, Yang, Du, Cong, Li, Jing, Yu, Jiaying, Xiao, Wenjun, Chen, Chen, Huang, Defa, Zhong, Tianyu, Li, Jiang, Xiang, Xi, Li, Zhigang |
| Předmět: |
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| Zdroj: |
Clinical & Translational Medicine; Oct2024, Vol. 14 Issue 10, p1-7, 7p |
| Abstrakt: |
The article in the Clinical & Translational Medicine journal explores the characterization and functional analysis of extrachromosomal circular DNA (eccDNA) found in circulating extracellular vesicles (EVs) in liver failure. The study involved 22 participants, including patients with liver failure and healthy individuals, and identified that liver failure patients had a higher abundance of EVs carrying eccDNAs compared to healthy controls. The research also synthesized artificial eccDNAs and found that eccZMIZ1-AS1 regulated specific signaling pathways in liver cells, potentially impacting liver failure pathogenesis. Further investigation is needed to understand the mechanisms by which eccDNA influences liver failure. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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