| Abstrakt: |
Researchers at San Raffaele Roma Open University conducted a study on the use of biocompatible poly(e-caprolactone) nanocapsules to enhance the bioavailability, antibacterial, and immunomodulatory activities of curcumin. The study aimed to improve curcumin's effectiveness by encapsulating it in nanocapsules and testing its stability, bioaccessibility, antibacterial activity, and impact on adipose-derived stem cells. The results showed that curcumin-loaded nanocapsules were stable post-gastric digestion, had increased bioaccessibility post-intestinal digestion, exhibited antibacterial activity against Escherichia coli, and modulated the expression of pro- and anti-inflammatory cytokines in stem cells. This research highlights the potential of nanocapsules to enhance curcumin's therapeutic efficacy in treating inflammatory diseases and intestinal dysbiosis. [Extracted from the article] |
