| Autor: |
Seyedinia, Seyed Ali, Bayat, Ali, Asadi, Ilia, Mohseni, Hossein, Vafaei, Abbas Ali, Raise-Abdullahi, Payman, Pour, Ali Rashidy |
| Zdroj: |
Koomesh: Journal of Semnan University of Medical Sciences; Jan2024, Vol. 26 Issue 1, p1-38, 15p |
| Abstrakt: |
Background:: Numerous studies have demonstrated that environmental enrichment (EE) can mitigate the impacts of chronic stress. In this study, we explored the influence of maternal environmental enrichment on cognitive-behavioral disorders stemming from stress in the offspring rats. Methods: Upon confirmation of pregnancy through the presence of vaginal plaque, the mother rats were randomly assigned to two groups: Control and enriched environment. The male and female pups were subsequently categorized into stress and non-stress groups. The stress groups experienced 6 hours of daily restraint stress for 21 days starting from the 30th day post-birth (adolescence). Serum corticosterone levels were measured after this period, and behavioral tests were conducted. Results: Restraint stress resulted in elevated serum corticosterone levels (P-value > 0.05). Data analysis from the elevated plus maze and light-dark box revealed an increase in the time spent and the number of entries into open arms in the offspring of the EE-St group compared to the STD-St group (P-value > 0.05). Light-dark box results demonstrated an increase in step-through latency and the number of entries into the lightbox in the offspring of the EE-St group compared to the STD-St group (P-value > 0.05). During the forced swimming test, immobility time was decreased in the offspring of the EE-St group compared to the STD-St group (P-value > 0.01). In the shuttle box test, step-through latency and the total time spent in the light compartment increased in the offspring in the EE-St group compared to the STD-St group (P-value > 0.01). Lastly, in the novel object recognition test, the time spent next to the new object increased in the EE-St offspring compared to the STD-St offspring (P-value > 0.01). Conclusion: Environmental enrichment during pregnancy diminished anxiety and depression-like disorders as well as cognitive defects induced by stress in the adolescent offspring rats. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
