| Autor: |
H., Sagar, Doddamani, G. B., Karpoor, Chandrashekhar, Bagewadi, Harish G., B. G., Devendrappa, A., Shivalee, Kallur, Rohini |
| Předmět: |
|
| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 9, p1540-1551, 12p |
| Abstrakt: |
Background: Diabetes mellitus is a widely prevalent disease that has apparently become a global epidemic. Hyperhomocysteinemia have a strong association with the onset of atherosclerosis. Elevated homocysteine in type-II DM causes endothelial cell damage by extravagant sulfation of collagen which increases risk of thrombosis and arteriosclerosis. Exploration of newer novel biomarkers in diabetes mellitus is a felt need to halt the disease prognosis and severity. Materials and Methods: In the present study, total 80 subjects were recruited. They were grouped into cases (n=40), type II diabetes mellitus patients and apparently healthy controls (n=40). Blood samples were collected for estimation of random blood sugar, HbA1c, serum homocysteine and lipid profile. Results: Homocysteine level (Hcy) among diabetic patients was 23.6 ± 11.4 µmol/L which was significantly higher than control group (9.54± 2.64 µmol/L, p < 0.001). Serum TG and VLDL were significantly higher among diabetic patients with hyperhomocysteinemia than diabetic patients with normal with serum homocysteine. Positive correlation of homocysteine was observed with RBS and HbA1c (r =0.562 and 0.743 respectively). Conclusion: Type 2 diabetes mellitus patients are at risk of having hyperhomocysteinemia which leads to dyslipidemia. There is a strong positive correlation between hyperhomocysteinemia and hyperglycemic state. This can be one of the important casual factor in pathogenesis of coronary heart disease events among diabetes patients. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
