| Autor: |
R., Thanu Shree, H., Rajeev, T. A., Shilpa, N., Abishek |
| Předmět: |
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| Zdroj: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research); 2024, Vol. 15 Issue 9, p1439-1448, 10p |
| Abstrakt: |
Background: Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Magnesium reportedly has immunomodulatory effects and is associated with dysregulated host response to infection and the pathophysiology of sepsis. Previous studies reported that hypomagnesemia was associated with lactic acidosis in sepsis, increased incidence of sepsis or septic shock in critically ill patients, and increased mortality in sepsis. Thus, this study is being conducted to explore the association between serum magnesium levels and coagulopathy in sepsis, outcomes. Materials: This cross-sectional study was performed on 40 Sepsis Cases Admitted in Intensive care Unit, Kempegowda institute of medical sciences during a 12-month period. SOFA score was calculated. Serum magnesium levels were estimated. Sepsis cases were categorized based on serum magnesium levels as low, normal, high on the day of diagnosis of sepsis. ISTH criteria will be used for diagnosis of overt DIC/coagulopathy in sepsis cases during the course in the hospital. Serum magnesium levels was independently associated with both coagulopathy/DIC and clinical outcome of sepsis cases. The data was collected and compiled in MS Excel. Descriptive statistics has been used to present the data. To analyse the data SPSS (Version 26.0) was used. Significance level was fixed as 5% (a = 0.05. Qualitative variables are expressed as frequency and percentages and Quantitative variables are expressed as Mean and Standard Deviation. To compare the association between numerical and categorical variables, student t test was used. Observation: The mean age of the study participants was found to be 58.75+17.299. 75% of the study participants were males. The mean serum magnesium levels were found to be 1.8798+0.56902. 67.5% of the study participants had low grade DIC and 32.5% of the study participants had overt DIC. The mortality rate in the present study was found to be 35%. The mean Serum magnesium of the study participants with Overt DIC were found to be lower than low grade DIC study participants (1.37+0.47vs2.12+0.44; P value=0.000). The mean Serum magnesium of the study participants who died were found to be lower than that of study participants who were discharged (1.59+0.60vs2.03+0.49; P value=0.019). Conclusion: Serum magnesium was found to be inversely related to DIC in sepsis patients and hypomagnesemia is associated with poor clinical outcome in sepsis patients. Consequently, treatment of hypomagnesemia may be a viable therapeutic approach for the prevention and management of coagulopathy in sepsis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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