| Abstrakt: |
Background: Renal stone disease is a common medical issue in many regions, leading to significant morbidity and loss of man hours. The disease predominantly affects the economically active population, thus having a socio economic impact. Unlike in the West, where detailed demographic data is available, India lacks comprehensive records on this condition. The prevailing theory is that kidney stones often serve as repositories for bacteria. The question which arises is whether bacterial infection is a precursor to or a result of stone formation. Multiple factors contributing to stone formation have been noted by various researchers. The healthcare burden in the United States alone includes over 185,000 hospital admissions and expenditures surpassing $2 billion annually. Supersaturation of calcium and oxalate in urine, exceeding their solubility limits, have been identified as a primary factor. This study evaluates the bacteriological profile of cultures derived from renal stones and their antibiotic sensitivities to better understand the microbial involvement in stone pathogenesis. Methods: This is a prospective, observational study aimed at analyzing the culture and sensitivity patterns of renal stones obtained from patients undergoing percutaneous and ureteroscopic stone extraction over a period of 18 months. Results: Out of 120 patients studied, 34 patients (28.3%) were culture positive. Of there, coagulase negative staphylococcus isolates noted in 9 patients (26.5%), E. coli was the next most common isolate seen in 8 patients (23.5%). Pseudomonas was noted in 6 patients (17.6%), other organisms in 5 patients (14.7%). Acinetobacter was isolated in 1 patient. Analysis of antibiotic susceptibility showed most of these sensitive to varying degrees to aminoglycosides and ciprofloxacin. Conclusion: In conclusion, culture and sensitivity testing of renal stones is a valuable tool in the management of nephrolithiasis, particularly in patients with recurrent or complicated infections. By identifying the bacterial organisms within the stones and determining their antibiotic susceptibility, clinicians can provide targeted treatment, improve patient outcomes, and reduce the risk of recurrenc. [ABSTRACT FROM AUTHOR] |
