| Autor: |
de la Torre, Rafael, Farré, Magí, Mathúna, Brian Ó., Roset, Pere N., Pizarro, Neus, Segura, Mireia, Torrens, Marta, Ortuño, Jordi, Pujadas, Mitona, Camí, Jordi |
| Předmět: |
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| Zdroj: |
European Journal of Clinical Pharmacology; Aug2005, Vol. 61 Issue 7, p551-554, 4p |
| Abstrakt: |
The article presents information on the neurotoxicity of MDMA (ecstacy). Ecstasy is a ring-substituted amphetamine widely abused by the youth for its euphoric and empathic effects. The cytochrome isoform (CYP2D6) gene is highly polymorphic and many variations affect the expression or activity of the enzyme. It is postulated that the chemical species involved in serotonergic neurotoxicity are catechol thiol conjugate metabolites of the drug. The fortuitous inclusion of a CYP2D6 poor metaboliser was the basis for examining the pharmacology of ecstacy from the perspective of CYP2D6 genotype. |
| Databáze: |
Complementary Index |
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