B cells: roles in physiology and pathology of pregnancy.

Autor: Jin-Chuan Liu, Qunxiong Zeng, Yong-Gang Duan, Yeung, William S. B., H. W. Li, Raymond, Ng, Ernest H. Y., Ka-Wang Cheung, Qingqing Zhang, Chiu, Philip C. N.
Předmět:
Zdroj: Frontiers in Immunology; 2024, p01-17, 17p
Abstrakt: B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet to be investigated. This review consolidates current knowledge on B cell activities and regulation during pregnancy, with a particular focus on the roles of various B cell subsets and the effects of B cell-derived factors on pregnancy outcomes. Moreover, the review examines the significance of B cell-associated autoantibodies, cytokines, and signaling pathways in relation to pregnancy complications such as pregnancy loss, preeclampsia, and preterm birth. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index