Electrochemically grafted gallic acid-chitosan: a metal-free in situ redox platform for regiospecific oligopeptide-viral spike protein interaction.

Autor: Krishnan, Vinoth, Sivakumar, Chinnaiah, Babu, Kannadasan Anand, Vigneswari, Sevakumaran, Lakshminarayanan, Rajamani, Natarajan, Sudhakar, Veerapandian, Murugan
Předmět:
Zdroj: Chemical Communications; 11/4/2024, Vol. 60 Issue 85, p12405-12408, 4p
Abstrakt: Electrochemical grafting of gallic acid with chitosan (EgGC) voltammetrically deposited on a multitude of substrates exhibiting reversible oxidoreduction suitable for sensor construction is reported. A bioreceptor customized from the fragment antigen binding region of SARS-CoV-2 neutralizing antibodies immobilized on an EgGC matrix supported the selective/specific electrochemical signal transduction with respect to different viral loads (femtogram level) of SARS-CoV-2. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index