| Abstrakt: |
Diabetic dyslipidemia causes cardiovascular-related death. Due to the complexity of this disorder, management may be complicated. We evaluated the effects of Citrus aurantifolia juice plasma glucose and lipids on diabetic Wister rats. Twenty-eight female rats were grouped into four of seven rats per group: group I (control), group II (non-diabetic rats treated with lime juice), group III (diabetic rat treated with lime juice) and group IV (diabetic rats not treated with lime juice). Diabetes was induced after an overnight fast by intraperitoneal injection of 120 mg/kg alloxan dissolved in 0.9v/v normal saline. The animals of groups I and IV were given daily treatment of 5 ml distilled water, while groups II and III were administered 5 ml lime juice for seven days. The plasma glucose and lipids were determined using the spectrophotometric method. Pre-lime treatment, glucose, total cholesterol (T. Chol), triglycerides (TG), and low-density lipoprotein (LDL) were significantly higher in diabetic rats compared to non-diabetic rats (p=0.000, 0.010, 0.002 and 0.012) while high-density lipoprotein (HDL) (p=0.008) was lower. Post-lime treatment, there was no significant difference in the concentrations of glucose, T. Chol, TG, HDL and LDL of group III compared to group I rats (p=0.010, 0.643, 0.653, 0.616 and 0.429, respectively). Administration of lime juice may be able to control glycaemic and dyslipidaemia states. We suggest that its application in the management of diabetes and its associated dyslipidaemia be explored. [ABSTRACT FROM AUTHOR] |
