| Abstrakt: |
Researchers at Albert Einstein College of Medicine conducted a study on the role of transforming growth factor (TGF)-b-induced fibroblast activation in diabetic cardiomyopathy. They found that fibroblast-specific TGF-b/Smad3 signaling mediates ventricular fibrosis, hypertrophy, and dysfunction in Type 2 diabetes. The study suggests that TGF-b-stimulated fibroblasts may have paracrine actions on cardiomyocytes in addition to their role in fibrous tissue deposition. This research was supported by various organizations including NIH, US Department of Defense, and the American Heart Association. [Extracted from the article] |
