Data from Chinese Academy of Sciences Advance Knowledge in Lung Cancer (HIF-1a-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma).

Předmět:	EPIDERMAL growth factor receptors CANCER cell proliferation METABOLIC reprogramming PURINE nucleotides ANALYTICAL chemistry
Zdroj:	Clinical Oncology Week; 10/22/2024, p270-270, 1p
Abstrakt:	A recent study from the Chinese Academy of Sciences explores the role of the HIF-1a-HPRT1 axis in promoting tumorigenesis and gefitinib resistance in EGFR-mutant lung adenocarcinoma. The research reveals that mutated EGFR upregulates HPRT1 to enhance purine metabolism, leading to rapid tumor cell proliferation. The study suggests that inhibiting purine metabolism could be a potential strategy for treating EGFR-mutant lung adenocarcinoma. [Extracted from the article]
Databáze:	Complementary Index
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