| Autor: |
Kuryshkina, M. S., Kulakova, A. M., Moskovsky, A. A., Khrenova, M. G. |
| Zdroj: |
Moscow University Chemistry Bulletin; Aug2024, Vol. 79 Issue 4, p257-261, 5p |
| Abstrakt: |
Photoregulated adenylate cyclases bPAC and OaPAC are compared using methods of classical molecular dynamics in the states before and after irradiation with light. The pathways of signal transduction from the photoreceptor domain to the catalytic domain are determined. The more pronounced acceleration of the catalytic reaction as a result of irradiation with light in the case of bPAC is determined both by a shift of the equilibrium towards a closed conformation and a more significant increase in the number of suboptimal pathways of allosteric signal transduction from one domain to another. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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