Design and Analysis of a Microplate Assay in the Presence of Multiple Restrictions on the Randomization.

Autor:	Bohyn, Alexandre, Schoen, Eric D., Ng, Chee Ping, Bishard, Kristina, Haarmans, Manon, Trietsch, Sebastian J., Goos, Peter
Předmět:	MICROPLATES DESIGN
Zdroj:	Journal of Agricultural, Biological & Environmental Statistics (JABES); Dec2024, Vol. 29 Issue 4, p745-765, 21p
Abstrakt:	Experiments using multi-step protocols often involve several restrictions on the randomization. For a specific application to in vitro testing on microplates, a design was required with both a split-plot and a strip-plot structure. On top of two-level treatment factors and the factors that define the randomization restrictions, a multi-level fixed blocking factor not involving further restrictions on the randomization had to be added. We develop a step-by-step approach to construct a design for the microplate experiment and analyze a response. To consolidate the approach, we study various alternative scenarios for the experiment.Supplementary materials accompanying this paper appear online [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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