| Autor: |
Liu, Mingxi, Li, Taiping, Zhao, Mengjie, Qian, Chunfa, Wang, Ran, Liu, Liang, Xiao, Yong, Xiao, Hong, Tang, Xianglong, Liu, Hongyi |
| Zdroj: |
Nanomedicine; 2024, Vol. 19 Issue 26, p2229-2249, 21p |
| Abstrakt: |
Glioblastoma (GBM), a highly invasive type of brain tumor located within the central nervous system, manifests a median survival time of merely 14.6 months. Radiotherapy kills tumor cells through focused high-energy radiation and has become a crucial treatment strategy for GBM, especially in cases where surgical resection is not viable. However, the presence of radioresistant tumor cells limits its clinical effectiveness. Radioresistance is a key factor of treatment failure, prompting the development of various therapeutic strategies to overcome this challenge. With the rapid development of nanomedicine, nanoradiosensitizers provide a novel approach to enhancing the effectiveness of radiotherapy. In this review, we discuss the reasons behind GBM radio-resistance and the mechanisms of radiotherapy sensitization. Then we summarize the primary types of nanoradiosensitizers and recent progress in their application for the radiosensitization of GBM. Finally, we elucidate the factors influencing their practical implementation, along with the challenges and promising prospects associated with multifunctional nanoradiosensitizers. Article highlights Enhanced radiosensitivity Nanoradiosensitizers significantly improve the radiosensitivity of glioblastoma, leading to more effective radiotherapy outcomes and reduced tumor resistance. Targeted delivery Nanoradiosensitizers can be engineered to selectively target glioma cells, minimizing damage to surrounding healthy brain tissue and enhancing the therapeutic index. Synergistic therapies Nanoradiosensitizers can be integrated with other treatments, such as chemotherapy or immunotherapy, to create synergistic effects that further inhibit glioma progression and improve patient outcomes. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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