Base-Catalyzed Reaction of Isatins and (3-Hydroxyprop-1-yn-1-yl)phosphonates as a Tool for the Synthesis of Spiro-1,3-dioxolane Oxindoles with Anticancer and Anti-Platelet Properties.

Autor: Murashkina, Arina V., Bogdanov, Andrei V., Voloshina, Alexandra D., Lyubina, Anna P., Samorodov, Alexandr V., Mitrofanov, Alexander Y., Beletskaya, Irina P., Smolyarchuk, Elena A., Zavadich, Kseniya A., Valiullina, Zulfiya A., Nazmieva, Kseniya A., Korunas, Vladislav I., Krylova, Irina D.
Předmět:
Zdroj: Molecules; Oct2024, Vol. 29 Issue 19, p4764, 14p
Abstrakt: An approach to the synthesis of phosphoryl substituted spiro-1,3-dioxolane oxindoles was developed from the base-catalyzed reaction of various isatins with (3-hydroxyprop-1-yn-1-yl)phosphonates. It was found that various aryl-substituted and N-functionalized isatins with the formation of appropriate products with high yields and stereoselectivity when using t-BuOLi are able to react. Cytotoxic activity evaluation suggests that the most significant results in relation to the HuTu 80 cell line were shown by N-benzylated spirodioxolanes. 5-Cloro-N-unsubstituted spirooxindoles exhibit antiaggregational activity exceeding the values of acetylsalicylic acid. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje