| Autor: |
Chiba, Shiho, Kiso, Maki, Yamada, Shinya, Someya, Kazuhiko, Onodera, Yoshikuni, Yamaguchi, Aya, Matsunaga, Satoko, Uraki, Ryuta, Iwatsuki-Horimoto, Kiyoko, Yamayoshi, Seiya, Takeshita, Fumihiko, Kawaoka, Yoshihiro |
| Předmět: |
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| Zdroj: |
NPJ Vaccines; 10/14/2024, Vol. 9 Issue 1, p1-5, 5p |
| Abstrakt: |
Highly pathogenic avian influenza (HPAI) H5 viruses from different clades have been circulating globally, threatening wild/domestic birds and mammals. Given frequent spillovers and high mortality among mammals, coupled with our inability to predict which clade of H5 virus has pandemic potential, cross-clade protective HPAI H5 vaccines are urgently needed. Here, we demonstrate the applicability of a lipid nanoparticle-based mRNA vaccine modality to induce cross-protective immunity against lethal HPAI virus infection. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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