Acute lymphoblastic leukemia in patients treated with lenalidomide for multiple myeloma: a safety meta-analysis of randomized controlled trials combined with a retrospective study of the WHO's pharmacovigilance database.

Autor: Morice, Pierre-Marie, Khalife-Hachem, Sabine, Sassier, Marion, Lelong-Boulouard, Véronique, Danu, Alina, Pasquier, Florence, Renneville, Aline, Dolladille, Charles, Micol, Jean-Baptiste
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Zdroj: Blood Cancer Journal; 10/14/2024, Vol. 14 Issue 1, p1-4, 4p
Abstrakt: A study published in the Blood Cancer Journal highlights an increased risk and incidence of acute lymphoblastic leukemia (ALL) in patients with multiple myeloma (MM) who were treated with lenalidomide. The study conducted a systematic review and safety meta-analysis of randomized controlled trials (RCTs) and analyzed data from the World Health Organization's pharmacovigilance database. The findings suggest that lenalidomide-associated ALL should be considered as a specific entity and may require better monitoring and patient information. Further research is needed to determine the risk and incidence of lenalidomide-associated ALL in non-MM diseases and to identify potential drug combinations that could increase this risk. [Extracted from the article]
Databáze: Complementary Index