Tyrosine kinase inhibitors versus thymoquinone in management of cancer: A mechanistic approach.

Autor: Nath, Suman Kumar, Garg, Madhukar, Babbar, Ritchu
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Zdroj: AIP Conference Proceedings; 2024, Vol. 3209 Issue 1, p1-9, 9p
Abstrakt: The second most common malignancy among women worldwide is breast cancer. Despite cutting-edge therapeutic options, systemic toxicity continues to be a serious side effect that increases patient morbidity and death. Natural goods have recently become a target for pharmacological due to their crucial functions. Primary source of natural substances utilised in medicine has been plants. However, the majority of herbal bioactive have a hydrophobic character, which limits their bioavailability and, consequently, their therapeutic potency. combining anticancer herbal bioactive with various nanocarriers is a promising approach to address some challenges associated with conventional cancer treatments. Nanocarriers are nanoscale delivery systems that can effectively transport therapeutic chemicals, including herbal bioactive to the body's target location while encapsulating and protecting them. Black cumin seed has been demonstrated in animal experiments to inhibit the formation of tumour cells and lessen the frequency of tumours. Patients with breast cancer who used an N. sativa gel topically saw a reduction. When the seed oil of N. sativa was given to breast cancerous cells (MCF-7) alone or in combination with doxorubicin, there was a reduction in cell survival and proliferation, revealing important opportunities in the area of cancer therapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index