| Abstrakt: |
Bombax ceiba Linnaeus (synonyms Bombax malabaricum (DC.)) is commonly known as sembal, exhibited varied pharmacological activities like aphrodisiac, antidiabetic, antiangiogenic, hepatoprotective, antimicrobial, antiproliferative activity, hypoglycaemic, hypotensive, anti-inflammatory, anti-anxiety and anticonvulsant etc. B. ceiba leaves are wealthy source of numerous phytoconstituents including polyphenols and flavonoids. As polyphenolic compounds contribute in the regulation of mental health including behaviour, brain plasticity, cognition, depression, and mood. So, it is considered worthwhile to investigate B. ceiba leaves for antidepressant activity. Solvents viz pet ether, CHCl3, methanol, and water were employed to extract B. ceiba leaves one after the other in ascending polarity sequence. Mice were given prepared crude extracts of B. ceiba leaves at 200 or 400 mg/kg conc. by oral route and its antidepressant potential was assessed using the FST and TST in comparison to imipramine, 15mg/kg, p.o. According to findings, solely methanol extract unveiled note worthy antidepressant effect at the dosage of 400 mg/kg in FST and TST which was statistically equivalent to imipramine. Additionally, the extract had no consequence on the mice's locomotor actions in the OFT. suggesting that the diminution in the immobility as prompted by methanolic extract was unrelated to the psycho-stimulant effect. Phytochemical investigations revealed the existence of flavonoids, phenolic compounds, alkaloids, triterpenoids and coumarins in bioactive methanol extract of B. ceiba leaves. [ABSTRACT FROM AUTHOR] |
