| Abstrakt: |
An efficient procedure is described to tritiate cocaine at high specific activity. Several tritium labelling methods were considered and evaluated against the goals of a robust synthesis employing a stable precursor, providing high radiochemical purity and specific activity [3H] cocaine of reasonable stability. Ultimately, the tritium dechlorination of a 3, 4-dichlorobenzoyl cocaine precursor became the radiolabelling method of choice. Experimental details are provided for the dichloro precursor preparation, tritium labelling as well as impure [3H] cocaine repurification. [ABSTRACT FROM AUTHOR] |
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