| Abstrakt: |
Scientists at St. Jude Children's Research Hospital have studied the structure of a eukaryotic CRISPR-Cas homolog called Fanzor2, which has potential for gene editing. Using cryo-electron microscopy, the researchers found that Fanzor2 has structural differences from other RNA-guided nucleases, providing insights for future protein engineering. Fanzor proteins are smaller than their Cas9 and Cas12 counterparts, making them more functional for genome engineering. The study's findings could lead to the development of novel approaches to RNA-guided nucleases and a better understanding of their structural diversity. [Extracted from the article] |
