| Předmět: |
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| Zdroj: |
Pharma Business Week; 10/14/2024, p1218-1218, 1p |
| Abstrakt: |
Scientists at the Scripps Research Institute have developed a new method called "paralog hopping" to design drugs that target difficult-to-reach proteins. By studying the structure of a protein's "twin" or paralog, the researchers were able to identify a druggable site and then characterize drugs that bound to a similar but harder-to-detect spot on the target protein. This approach could lead to the discovery of new binding sites for drugs and inform drug development for proteins involved in cancer and autoimmune diseases. The researchers plan to apply this method to other protein pairs important for tumorigenesis. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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