| Autor: |
Toshalieva, Saodat, Hussein, Uday Abdul-Reda, Nabee, Aya, Mohammed, Faraj, Mohammed, Rand, Ahmed, Batool Ali, Shaghnab, Murtadha Lafta, Alyas, Mohamad Adnan, Khurramov, A., ugli, Bobojonov Otabek Khakimboy, Khurshida, Burieva, Arabova, Nodira, Uktamovna, Bekmukhamedova Barno |
| Předmět: |
|
| Zdroj: |
Journal of Nanostructures; Winter2024, Vol. 14 Issue 1, p65-72, 8p |
| Abstrakt: |
The widespread use of silica nanoparticles (SiNPs) in various applications has raised concerns about their potential health effects, particularly regarding pulmonary toxicity. The purpose of this analysis was to delve into the dose-dependent pulmonary effects of SiNPs following subchronic inhalation exposure in rats. Adult male rats, specifically of the Sprague-Dawley breed, experienced filtered air (control), 1 mg/m³ (low-dose), or 10 mg/m³ (high-dose) of SiNPs (mean diameter 52.3 ± 4.7 nm) for 6 hours/day, 5 days/week, for 13 weeks. Pulmonary function tests were conducted periodically. At study termination, bronchoalveolar lavage fluid (BALF) was analyzed for inflammatory markers, and lung tissues were examined histopathologically. High-dose SiNP exposure led to significant impairment of lung function, characterized by decreased tidal volume (19.2%), increased respiratory rate (15.7%), reduced lung compliance (24.1%), and increased airway resistance (54.5%). Both low and high-dose exposures induced dose-dependent pulmonary inflammation, evidenced by increased total cell counts, neutrophil infiltration, and elevated pro-inflammatory cytokine levels in BALF. Histopathological examination revealed dose-dependent structural changes in lung tissues, encompassing increased alveolar wall thickness, overgrowth of alveolar epithelium, and inflammation in both alveoli and bronchioles. Notably, granuloma formation was observed in 62.5% of rats in the high-dose group. Subchronic inhalation exposure to SiNPs induces dosedependent pulmonary toxicity in rats, characterized by impaired lung function, persistent inflammation, and structural changes in lung tissues. These findings highlight the possible hazards linked to extended contact with SiNPs and underscore the importance of implementing appropriate safety measures in occupational settings where SiNP exposure may occur. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
