A T cell receptor specific for an HLA-A*03:01-restricted epitope in the endogenous retrovirus ERV-K-Env exhibits limited recognition of its cognate epitope.

Autor: Grundy, Erin E., Shaw, Lauren C., Wang, Loretta, Lee, Abigail V., Argueta, James Castro, Powell Jr, Daniel J., Ostrowski, Mario, Jones, R. Brad, Cruz, C. Russell Y., Gordish-Dressman, Heather, Chappell, Nicole P., Bollard, Catherine M., Chiappinelli, Katherine B.
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Zdroj: Mobile DNA; 10/9/2024, Vol. 15 Issue 1, p1-18, 18p
Abstrakt: Transposable elements (TEs) are often expressed at higher levels in tumor cells than normal cells, implicating these genomic regions as an untapped pool of tumor-associated antigens. In ovarian cancer (OC), protein from the TE ERV-K is frequently expressed by tumor cells. Here we determined whether the targeting of previously identified epitope in the envelope gene (env) of ERV-K resulted in target antigen specificity against cancer cells. We found that transducing healthy donor T cells with an ERV-K-Env-specific T cell receptor construct resulted in antigen specificity only when co-cultured with HLA-A*03:01 B lymphoblastoid cells. Furthermore, in vitro priming of several healthy donors with this epitope of ERV-K-Env did not result in target antigen specificity. These data suggest that the T cell receptor is a poor candidate for targeting this specific ERV-K-Env epitope and has limited potential as a T cell therapy for OC. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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