Efficacy and tolerability of SEDIFLÙ in treating dry or productive cough in the pediatric population (SEPEDIA): A pilot, randomized, double-blind, placebo-controlled, multicenter clinical trial.
| Autor: | Núñez, Carlos, Chiatti, María Cristina, Tansella, Francesco, Coronel-Rodríguez, Cristóbal, Risco, Ester |
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| Předmět: |
PLACEBOS
STATISTICAL significance RESEARCH funding HERBAL medicine STATISTICAL sampling PILOT projects BLIND experiment QUESTIONNAIRES RANDOMIZED controlled trials SEVERITY of illness index TREATMENT effectiveness DESCRIPTIVE statistics PLANT extracts LONGITUDINAL method HONEY DRUG efficacy RESEARCH COUGH EUCALYPTUS SLEEP quality PSYCHOLOGY of parents COMPARATIVE studies DATA analysis software DRUG tolerance EVALUATION CHILDREN |
| Zdroj: | Clinical Pediatrics; Nov2024, Vol. 63 Issue 11, p1510-1519, 10p |
| Abstrakt: | The aim of this trial was to assess the effectiveness of Sediflù, a medical device containing active herbal ingredients, on nocturnal and diurnal persistent coughs in children, with a duration of 3 to 7 days. Children with a dry and/or productive cough were enrolled in this prospective, interventional, multicenter, placebo-controlled, double-blind, randomized clinical study. Clinical efficacy was assessed through the evaluation of the soothing action of Sediflù against dry and/or productive coughing, both at night and during the day, and other effects of coughing associated with quality of sleep: frequency, child's quality of sleep, parental quality of sleep and severity. Treatment with Sediflù improved both night-time and day-time cough scores from day 2. The diurnal score also improved significantly in the Sediflù group at days 3 and 7. Sediflù syrup can be considered a valid treatment for cough management in younger children with upper respiratory tract infections, shortening the cough duration. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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