| Autor: |
Suzuki, Hirotsugu, Takemura, Yosuke, Matsuda, Takanori |
| Předmět: |
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| Zdroj: |
Synlett; Oct2024, Vol. 35 Issue 17, p2037-2041, 5p |
| Abstrakt: |
We developed a redox-neutral synthesis of isoindoloindolone via intramolecular arylation of 2-(1 H -indole-1-carbonyl)benzoic acids. This protocol facilitates the formation of various substituted isoindoloindolones in yields ranging from 17% to 80%. Our mechanistic investigations indicate the pivotal role of NaI: the iodide anion promotes the formation of the desired isoindoloindolone, and the sodium cation suppresses the formation of acylated byproducts, thereby enabling the selective formation of isoindoloindolones in acceptable yields. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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