| Abstrakt: |
Axial spondyloarthritis (axSpA) is a complex disease characterized by a diverse range of clinical presentations. The primary manifestation is inflammatory lower back pain, often accompanied by other clinical manifestations such as peripheral arthritis, enthesitis, uveitis, psoriasis, and inflammatory bowel disease. However, the presentation of axSpA can vary widely among patients. Despite extensive research, the precise pathogenesis of axSpA remains largely unknown. The lack of complete understanding poses challenges in subgrouping the disease, developing specific treatment approaches, and predicting treatment response. In this review, we will explore the limitations in diagnosing and treating axSpA. In addition, we will examine the current knowledge and potential opportunities provided by various omics and technological advancements in enhancing the diagnosis and personalized treatment of axSpA. Plain language summary: Precision medicine in axial spondyloarthritis: current opportunities and future perspectives The precise pathogenesis of axSpA remains unknown and is likely to be complex. Further efforts are needed to understand the disease mechanism to improve patient classification. Precision diagnosis integrates genetic data, environmental factors, and clinical characteristics to define subcategories. With the rapid advancement of technology, conducting more studies on the mechanism of SpA using multi-omics technology may yield new insights into the disease. It is also important to strike a balance between early treatment and avoiding overtreatment. Future studies should aim to combine multi-omic data, allowing the development of a more precise and individualized treatment strategy for SpA patients. [ABSTRACT FROM AUTHOR] |
