| Autor: |
Khan, Anas U., Irwin, Zachary, Mahavadi, Anil, Roller, Anna, Goodman, Adam M., Guthrie, Barton L., Visscher, Kristina, Knight, Robert T., Walker, Harrison C., Bentley, J. Nicole |
| Předmět: |
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| Zdroj: |
Journal of Neuroscience; 10/2/2024, Vol. 44 Issue 40, p1-11, 11p |
| Abstrakt: |
Executive control of movement enables inhibiting impulsive responses critical for successful navigation of the environment. Circuits mediating stop commands involve prefrontal and basal ganglia structures with fMRI evidence demonstrating increased activity during response inhibition in the dorsolateral prefrontal cortex (dlPFC)—often ascribed to maintaining task attentional demands. Using direct intraoperative cortical recordings in male and female human subjects, we investigated oscillatory dynamics along the rostral-caudal axis of dlPFC during a modified Go/No-go task, probing components of both proactive and reactive motor control. We assessed whether cognitive control is topographically organized along this axis and observed that low-frequency power increased prominently in mid-rostral dlPFC when inhibiting and delaying responses. These findings provide evidence for a key role for mid-rostral dlPFC low-frequency oscillations in sculpting motor control. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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