| Autor: |
Batool, Iram, Zafar, Nadiah, Ahmad, Zulcaif, Mahmood, Asif, Sarfraz, Rai Muhammad, Shchinar, Saniia, Ayub, Sadaf |
| Zdroj: |
BioNanoScience; Sep2024, Vol. 14 Issue 3, p2131-2144, 14p |
| Abstrakt: |
Transdermal drug delivery methods offer significant advantages over oral or hypodermic alternatives. By avoiding the initial breakdown of medication in the liver and stomach, these methods provide patients with greater convenience through a less invasive and painless process. A state-of-the-art transdermal drug delivery device has recently been developed that combines nanoparticles with dissolving microneedles. This innovative approach aims to enhance the transdermal delivery of letrozole, a cancer-fighting medication. The formulated mixture exhibited impressive anticancer effects due to targeted delivery facilitated by the attachment of folic acid to the nanoparticles, allowing penetration through the skin. The compatibility of ingredients was confirmed by FTIR analysis. The microneedle patch was manufactured and tested both in laboratory settings and on live subjects to evaluate its mechanical strength, ability to penetrate the skin, drug release characteristics, and any potential skin irritation. The microneedle patch, consisting of 100 needles measuring 575 μm, exhibited strong mechanical properties with no breakage during skin penetration. Histological analysis of mouse skin indicated successful needle penetration into the dermis. The prepared microneedle patch exhibited significant cytotoxic effects on MCF-7 breast cancer cells, with an IC50 value of 50 μM, suggesting its potential as an effective anticancer treatment. Ex vivo permeation studies using Franz diffusion cells demonstrated sustained release of letrozole, with significantly enhanced skin permeation compared to controls (p < 0.05). Furthermore, in vivo testing on rabbits confirmed the safety and biocompatibility of the material and patch. Overall, this study demonstrates the successful development of a folic acid-targeted, silver nanoparticle-loaded microneedle patch for the transdermal delivery of letrozole, offering a promising approach for breast cancer therapy. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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