Researchers from University of Alabama Detail New Studies and Findings in the Area of Seizures (Glial expression of Drosophila UBE3A causes spontaneous seizures that can be modulated by 5-HT signaling).

Předmět:	NEUROLOGICAL disorders SEIZURES (Medicine) HIDDEN Markov models SEROTONIN uptake inhibitors MECHANICAL shock
Zdroj:	Genomics & Genetics Weekly; 10/11/2024, p1815-1815, 1p
Abstrakt:	Researchers from the University of Alabama have conducted a study on seizures and the role of the UBE3A gene in neurological disorders. The study used a Drosophila model of Dup15q syndrome to investigate the effects of glial and neuronal expression of the UBE3A ortholog dube3a on motor coordination and seizure susceptibility. The researchers found that glial-driven dube3a expression led to spontaneous seizures and aberrant spike discharges, while neuronal-driven expression did not. They also discovered that certain 5-HT modulators could suppress seizure activity in the glial-driven dube3a flies. These findings suggest that glial pathophysiology may contribute to seizure activity in Dup15q syndrome. [Extracted from the article]
Databáze:	Complementary Index
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