Study Findings from University of Oslo Update Knowledge in Transforming Growth Factors (Legumain is a paracrine regulator of osteoblast differentiation and mediates the inhibitory effect of TGF-b1 on osteoblast maturation).

Předmět:	CONNECTIVE tissue cells SIGNAL peptides REPORTERS & reporting GENE expression BONE marrow
Zdroj:	Genomics & Genetics Weekly; 10/11/2024, p2114-2114, 1p
Abstrakt:	A study conducted by researchers at the University of Oslo has uncovered new information about the role of transforming growth factor-beta 1 (TGF-b1) in osteoblast maturation. The study found that TGF-b1 inhibits osteoblast maturation by stimulating the secretion and activity of legumain, a lysosomal protease. Additionally, TGF-b1 enhances the internalization and activation of extracellular prolegumain. These findings provide a deeper understanding of the regulation of osteoblastogenesis and offer insights for potential therapeutic interventions for bone diseases associated with abnormal TGF-b1 signaling. [Extracted from the article]
Databáze:	Complementary Index
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