| Autor: |
Perez-de-Llano, Luis, Scelo, Ghislaine, Tran, Trung N., Le, Tham T., Fagerås, Malin, Cosio, Borja G., Peters, Matthew, Pfeffer, Paul E., Al-Ahmad, Mona, Al-Lehebi, Riyad O., Altraja, Alan, Bergeron, Celine, Bjermer, Leif H., Bjerrum, Anne S., Bulathsinhala, Lakmini, Busby, John, Cano Rosales, Diana J., Canonica, Giorgio W., Carter, Victoria A., Charriot, Jeremy |
| Předmět: |
|
| Zdroj: |
American Journal of Respiratory & Critical Care Medicine; 10/1/2024, Vol. 210 Issue 7, p869-880, 12p |
| Abstrakt: |
Rationale: There is no consensus on criteria to include in an asthma remission definition in real life. Factors associated with achieving remission after biologic initiation remain poorly understood. Objectives: To quantify the proportion of adults with severe asthma achieving multidomain-defined remission after biologic initiation and identify prebiologic characteristics associated with achieving remission that may be used to predict it. Methods: This was a longitudinal cohort study using data from 23 countries from the International Severe Asthma Registry. Four asthma outcome domains were assessed in the 1 year before and after biologic initiation. A priori–defined remission cutoffs were: 0 exacerbations/yr, no long-term oral corticosteroid (LTOCS), partly/well-controlled asthma, and percent predicted FEV1 ⩾ 80%. Remission was defined using two (exacerbations + LTOCS), three (+control or +lung function), and four of these domains. The association between prebiologic characteristics and postbiologic remission was assessed by multivariable analysis. Measurements and Main Results: A total of 50.2%, 33.5%, 25.8%, and 20.3% of patients met criteria for two-, three- (+control), three- (+lung function), and four-domain remission, respectively. The odds of achieving four-domain remission decreased by 15% for every additional 10 years of asthma duration (odds ratio, 0.85; 95% confidence interval, 0.73–1.00). The odds of remission increased in those with fewer exacerbations per year, lower LTOCS daily dose, better control, and better lung function before biologic initiation. Conclusions: One in five patients achieved four-domain remission within 1 year of biologic initiation. Patients with less severe impairment and shorter asthma duration at initiation had a greater chance of achieving remission after biologic treatment, indicating that biologic treatment should not be delayed if remission is the goal. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
