| Autor: |
Peesapati, Ria S., Austin-Byler, Brianna L., Nawaz, Fathima Zahra, Stevenson, Jonathan B., Mais, Stanelle A., Kaya, Rabia N., Hassan, Michael G., Khanal, Nabraj, Wells, Alexandra C., Ghiai, Deena, Garikapati, Anish K., Selhub, Jacob, Kipreos, Edward T. |
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| Zdroj: |
Nature Communications; 9/30/2024, Vol. 15 Issue 1, p1-16, 16p |
| Abstrakt: |
Folates are B-group vitamins that function in one-carbon metabolism. Here we show that a specific folate can activate serotonergic neurons in C. elegans to modulate behavior through a pathway that requires the folate receptor FOLR-1 and the GON-2 calcium channel. FOLR-1 and GON-2 physically interact in a heterologous system, and both are expressed in the HSN and NSM serotonergic neurons. Both the folate 10-formyl-THF and a non-metabolic pteroate induce increases in the number of Ca2+ transients in the HSN neurons and egg laying in an FOLR-1- and GON-2-dependent manner. FOLR-1 and GON-2 are required for the activation of the NSM neurons in response to 10-formyl-THF, and for full NSM-mediated stoppage of movement when starved animals encounter bacteria. Our results demonstrate that FOLR-1 acts independently of one-carbon metabolism and suggest that 10-formyl-THF acts as a dietary signal that activates serotonergic neurons to impact behavior through a pathway that involves calcium entry. Folates are B vitamins that are known to be important for embryonic development and other important processes. Here, the authors show that a specific folate acts as a signal to activate serotonergic neurons to control behavior in C. elegans via a metabolism-independent pathway that requires the folate receptor and a calcium channel. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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