| Autor: |
Wu, Dengfeng, Fang, Chunying, Chen, Yazhi, Xu, Xuefeng, Wu, Xiongbo, Chen, Sijie |
| Zdroj: |
Molecular & Cellular Toxicology; Oct2024, Vol. 20 Issue 4, p949-958, 10p |
| Abstrakt: |
Background: Gastric cancer (GC) is threatening public health as there are at least one million new cases reported each year. Rhomboid domain-containing protein 1 (SEC61G) has been identified to regulate tumor cell survival, metastasis and cellular response by regulating glycolysis. However, the function of SEC61G in gastric cancer is not fully understood. Objectives: To investigate the effect of SEC61G on proliferation, epidermal growth factor receptor (EGFR) and glycolysis levels on GC, as well as the sensitivity of GC to etoposide. Results: SEC61G is highly expressed in gastric cancer tissues and gastric cell lines. SEC61G knockdown suppresses the cell viability and EdU incorporation. Meanwhile, SEC61G knockdown attenuated the phosphorylation of EGFR and AKT. SEC61G knockdown suppressed the migration, invasion, glucose uptake, lactate release and ATP production, while elevated oxygen consumption rate (OCR), promoting the sensitivity of gastric cancer to etoposide. Conclusions: SEC61G knockdown weakened the proliferation, EGFR phosphorylation and glycolysis of gastric cancer cells, as well as increased the sensitivity of gastric cancer to etoposide, which make SEC61G a promising therapeutic target for gastric cancer treatment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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