| Autor: |
Fornari, Chiara, Arrieta, Antonio, Bradley, John S., Tout, Mira, Magalhaes, Paulo, Auriol, Faten Koraichi, Borella, Elisa, Piana, Chiara, Della Pasqua, Oscar, Vallespir, Bartomeu Piza, Mazzei, Paolo, Bokesch, Paula M., Hoover, Randall, Capriati, Angela, Habboubi, Nassir |
| Předmět: |
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| Zdroj: |
British Journal of Clinical Pharmacology; Oct2024, Vol. 90 Issue 10, p2597-2610, 14p |
| Abstrakt: |
Aims: Meropenem/vaborbactam combination is approved in adults by FDA and EMA for complicated urinary tract infections and by EMA also for other Gram‐negative infections. We aimed to characterise the pharmacokinetics of both moieties in an ongoing study in children and use a model‐based approach to inform adequate dosing regimens in paediatric patients. Methods: Over 4196 blood samples of meropenem and vaborbactam (n = 414 subjects) in adults, together with 114 blood samples (n = 39) in paediatric patients aged 3 months to 18 years were available for this analysis. Data were analysed using a population with prior information from a pharmacokinetic model in adults to inform parameter estimation in children. Simulations were performed to assess the suitability of different dosing regimens to achieve adequate probability of target attainment (PTA). Results: Meropenem/vaborbactam PK was described with two‐compartment models with first‐order elimination. Body weight and CLcr were significant covariates on the disposition of both drugs. A maturation function was evaluated to explore changes in clearance in neonates. PTA ≥90% was derived for children aged ≥3 months after 3.5‐h IV infusion of 40 mg/kg Q8h of both meropenem and vaborbactam and 2 g/2 g for those ≥50 kg. Extrapolation of disposition parameters suggest that adequate PTA is achieved after a 3.5‐h IV infusion of 20 mg/kg for neonates and infants (3 months). Conclusions: An integrated analysis of adult and paediatric data allowed accurate description of sparsely sampled meropenem/vaborbactam PK in paediatric patients and provided recommendations for the dosing in neonates and infants (3 months). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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