The Effect of Systemic Endotoxinemia on the Structure of the Brachiocephalic Artery Wall or a Potential Clinical Model for Assessing the Efficacy of Anti-Aging Measures.

Autor: Pokusaeva, D. P., Anikhovskaya, I. A., Morozov, S. G., Yakovlev, M. Yu.
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Zdroj: Human Physiology; Apr2024, Vol. 50 Issue 2, p163-170, 8p
Abstrakt: Integral indicators of systemic endotoxemia (SEE): the level of endotoxin (ET) and the concentration of antibodies against the hydrophobic (AB-LPS-PHOB) and hydrophilic (AB-LPS-PHIL) forms of the lipopolysaccharide molecule (LPS) in the general circulation, can be used to determine the risk category of the development and progression of atherosclerosis whose dynamics is an objective marker of aging rate. The comparison of images of the structure of the brachiocephalic artery wall in dynamics with changes in blood parameters is one of the most successful models for monitoring the atherosclerotic process in the clinical setting. In total, 42 subjects without recognized risk factors for the progression of atherosclerosis were examined at baseline and after 1.5–2 years. It was found that lipid profile indicators, such as the concentration of total cholesterol, low- and high-density lipoproteins, triglycerides, and the atherogenic index were of no prognostic value. While in the group with progression of damage to the arterial wall, an increase in the ET concentration and a decrease in the AB-LPS-PHOB and AB-LPS-PHIL concentrations were noted. In the group with regression of atherosclerotic changes, on the contrary, there was an AB increase against the background of a decrease in the ET concentration. A prospective study revealed an extremely important fact of a decrease in the LPS concentration in the blood of patients with positive dynamics of morphological manifestations of atherosclerosis, indicating both the reversibility of the atherosclerotic process and the involvement of ET in atherogenesis. This is a real way of extending the life span of an individual, which shows the perspective of how to achieve this goal, which is antiendotoxin therapy. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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