Investigators at Hospital Universitario La Paz Report Findings in Rheumatoid Arthritis (Transiently Increased Circulating Cd39+foxp3+ Treg Cells Predicts the Clinical Response To Methotrexate In Early Rheumat.

Předmět:	JOINT diseases REGULATORY T cells MUSCULOSKELETAL system diseases ADENINE nucleotides JOINTS (Anatomy)
Zdroj:	Genomics & Genetics Weekly; 10/4/2024, p387-387, 1p
Abstrakt:	A recent study conducted at Hospital Universitario La Paz in Madrid, Spain, has found that an elevated frequency of CD39+FoxP3+ regulatory T cells in the blood predicts the clinical response to methotrexate (MTX) in early rheumatoid arthritis (eRA) patients. These T cells have the ability to control inflammation by releasing the anti-inflammatory agent adenosine. The study also found that MTX enhances the potency of these T cells. The researchers suggest that the baseline frequency of CD39+FoxP3+ T cells could be used as a predictor for the response to MTX treatment in eRA patients. [Extracted from the article]
Databáze:	Complementary Index
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