| Abstrakt: |
A recent study conducted at Henry Ford Hospital focused on understanding the role of cancer-associated fibroblasts (CAFs) in pancreatic cancer. CAFs are responsible for creating an immunosuppressive environment in tumors, hindering the effectiveness of immunotherapies. The researchers found that CAFs produce high levels of glutamate, which can be converted into gamma-aminobutyric acid (GABA), a major immunosuppressive metabolite. Interestingly, the study discovered a non-canonical pathway used by CAFs to produce GABA, involving the expression of specific enzymes. Further research aims to identify the cytokine profile of CAFs and analyze tumor interstitial fluid to improve clinical outcomes for pancreatic cancer patients. [Extracted from the article] |
