| Autor: |
de Mello Gindri, Izabelle, Ferrari, Gustavo, da Silva, Loise Silveira, Salmoria, Gean Vitor, de Mello Roesler, Carlos Rodrigo |
| Předmět: |
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| Zdroj: |
Polymer Bulletin; Oct2024, Vol. 81 Issue 15, p14143-14159, 17p |
| Abstrakt: |
To manufacture, feature and analyze the potential of materials to be used as raw material for drug delivery systems for the treatment of overactive bladder. Four distinct mixtures of oxybutynin and polymers ethylene vinyl acetate (EVA) and high-density polyethylene (PE) were prepared via compression molding and hot melt extrusion. The materials were characterized regarding their physicochemical and mechanical properties as well as drug release potential. Promising results were obtained in which the release of oxybutynin was observed for more than 250 days from both EVA and HDPE matrices. The obtained data demonstrate it is possible to manufacture HDPE- and EVA-based samples with the incorporation of oxybutynin, and the EVA samples presented an adequate release profile. The results are promising for the development of an intravesical device with drug delivery, especially because super dose risk is extinguished when considering the release from a monolithic release system. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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