Autor: |
Mutombo Mianda, Sephora, Moyo, Phanankosi, Maboane, Suzan, Birkholtz, Lyn‑Marié, Maharaj, Vinesh J. |
Předmět: |
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Zdroj: |
Natural Product Research; Oct2024, Vol. 38 Issue 20, p3542-3554, 13p |
Abstrakt: |
Three new steroids, turranin M, N and O (1-3), together with four known limonoids, nymania 1 (4), rubralin B (5), aphapolynin C (6) and Trichillia substance Tr B (7), were isolated from the leaves of Turraea obtusifolia. Their chemical structures were elucidated using NMR and MS. Rubralin B (5) displayed good activity against the asexual parasites from the drug sensitive Plasmodium falciparum NF54 strain with an IC50 value of 3.47 µg/mL (4.57 µM), nymania 1 (4) showed a weak activity (IC50 13.36 µg/mL (19.40 µM)) and the rest of compounds had IC50 > 20 µg/mL. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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