| Autor: |
Wongsurakiat, Phunsup, Rattanawongpaibul, Akrawat, Limsukon, Atikun, Chiewchalermsri, Chirawat, Wiwatcharagoses, Kittiyaporn, Kornthatchapong, Kumpol, Saiphoklang, Narongkorn, Sanguanwit, Pitsucha, Domthong, Pornanan, Kawamatawong, Theerasuk, Sewatanon, Tirachat, Reechaipichitkul, Wipa, Maneechotesuwan, Kittipong |
| Předmět: |
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| Zdroj: |
Journal of Asthma; Oct2024, Vol. 61 Issue 10, p1136-1151, 16p |
| Abstrakt: |
Objective: This study investigated the utilization of nebulized budesonide for acute asthma and COPD exacerbations as well as for maintenance therapy in adults. Data Sources: We conducted a search on PubMed for nebulized budesonide treatment. Selected Studies: Selecting all English-language papers that utilize Mesh phrases "asthma," "COPD," "budesonide," "nebulized," "adult," "exacerbation," and "maintenance" without temporal restrictions, and narrowing down to clinical research such as RCTs, observational studies, and real-world studies. Results: Analysis of 25 studies was conducted to assess the effectiveness of nebulized budesonide in asthma (n = 10) and COPD (n = 15). The panel in Thailand recommended incorporating nebulized budesonide as an additional or alternative treatment option to the standard of care and systemic corticosteroids (SCS) based on the findings. Conclusion: Nebulized budesonide is effective and well-tolerated in treating asthma and COPD, with less systemic adverse effects compared to systemic corticosteroids. High-dose nebulized budesonide can enhance clinical outcomes for severe and mild exacerbations with slow systemic corticosteroid response. Nebulized budesonide can substitute systemic corticosteroids in some situations. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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