A patient with positive anti‐IFN‐γ autoantibody and monoclonal gammaglobulinemia masquerading as multiple myeloma: Case report and literature review.

Autor: An, Ran, Liu, Zhiyin, Luo, Fangxiu, Yan, Zeying, Wang, Ying, Sun, Haimin, Tian, Jie, Chen, Yu, Chen, Yubao
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Zdroj: Clinical Case Reports; Sep2024, Vol. 12 Issue 9, p1-7, 7p
Abstrakt: Key Clinical Message: Adult‐onset immunodeficiency (AOID) is an emerging acquired immunodeficiency, characterized by multiple opportunistic infections including non‐tuberculous mycobacterium (NTM) due to the presence of anti‐IFN‐γ autoantibody (AIGA). This case highlights the challenges of accurate diagnosis of monoclonal gammaglobulinemia with NTM infection and favorable outcomes of anti‐plasma cell therapy in AOID. Adult‐onset immunodeficiency (AOID) is an emerging acquired immunodeficiency due to anti‐IFN‐γ autoantibody (AIGA) with low morbidity, frequent disseminated infections, a prolonged course, difficult diagnosis and treatment, and a poor prognosis. Here, we report a patient with positive AIGA and monoclonal gammaglobulinemia who was mimicking symptomatic multiple myeloma and resulting in a non‐tuberculous mycobacterial (NTM) infection. While he achieved an excellent therapeutic effect with anti‐plasma cell therapy, it also serves as a warning that monoclonal gammaglobulinemia with NTM infection is easily misdiagnosed as symptomatic multiple myeloma, and the screening for AIGA should not be ignored in patients with NTM infection. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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