Is There a Relationship Between Carbon Dioxide Fluctuations and Intraventricular Hemorrhage in Preterm Infants?

Autor: Şimşek, Gülsüm Kadıoğlu, Bilgin, Betül Siyah, Türk, Şeyma Bütün, Tufan, Nihan, Kutman, H. Gözde Kanmaz, Canpolat, Fuat Emre
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Zdroj: Cam ve Sakura Medical Journal; 2024, Vol. 4 Issue 2, p70-74, 5p
Abstrakt: Objective: This study aimed to examine the association between hypo/hypercapnia and fluctuations in carbon dioxide (CO2) levels and severe intraventricular hemorrhage (IVH) during the initial 72 hours of life among preterm infants. Material and Methods: A retrospective study of premature infants with birth weights between 750 and 1.250 g and gestational ages of 30 weeks who required respiratory support. Blood gas measurements were collected during the first 3 days of life. Multivariate analyses were performed to assess the association between hypercapnia and carbon dioxide pressure (pCO2) fluctuations and IVH. Results: Our cohort included 376 patients with a median gestational age of 28 weeks and a median birth weight of 920 g. After controlling for gestational age and birth weight, histologic chorioamnionitis and pCO2 fluctuations remained significantly associated with severe IVH. Conclusion: Fluctuations in pCO2 over a short period may have a stronger association with severe IVH than the mere occurrence of hypo- or hypercapnia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index