Peiminine alleviate coliti-like phenotype in mice induced by lead exposure.
| Autor: | Zhang, Jing, Wang, Chenchen, He, Yixuan, Wang, Ying, Fang, Xinbei, Shi, Meimei, Chen, Hui, Zhang, Jianbin, Zou, Haijiang |
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| Předmět: |
COLITIS prevention
THERAPEUTIC use of alkaloids LEAD exposure COLITIS ANTI-inflammatory agents IN vitro studies BIOLOGICAL models NF-kappa B EPITHELIAL cells INTESTINES ALKALOIDS RESEARCH funding APOPTOSIS IN vivo studies DESCRIPTIVE statistics CELLULAR signal transduction MICE EXPERIMENTAL design ANIMAL experimentation MOLECULAR structure INFLAMMATION PHENOTYPES DISEASE risk factors |
| Zdroj: | International Journal of Environmental Health Research; Oct2024, Vol. 34 Issue 10, p3363-3375, 13p |
| Abstrakt: | The deleterious impact of lead (Pb) pollution on human health is evident in both domestic and occupational settings, provoking an inflammatory response across multiple tissue, limited attention has been devoted to its adverse effects on colitis and the underlying mechanisms. Peiminine (PMI) has been recognized for its anti-inflammatory properties, yet its specific anti-inflammatory effects in lead-induced colitis models remain elusive. Through the establishment of both in vivo and in vitro lead exposure models, suggests that lead exposure can induce colitis and that PMI regulates lead exposure-induced colitis by inhibiting the NF-kB signaling pathway, and alleviates the ability of lead to apoptosis and inflammation levels in intestinal epithelial cells. Consequently, these results present a promising avenue for further exploration of the molecular mechanisms underlying lead-induced colitis, evaluation of the associated risks linked to lead exposure, and the development of therapeutic interventions for colitis resulting from lead exposure. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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