| Abstrakt: |
A recent study conducted by researchers from the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard University has explored the cellular heterogeneity and transcriptional changes in pediatric high-grade gliomas (pHGGs) during disease progression. The study analyzed 24 matched pHGG samples from children, adolescents, and young adults at both diagnosis and recurrence. The researchers identified two distinct global response sets activated at recurrence, with hemispheric tumors showing upregulation of extracellular matrix pathways and midline tumors activating generic stress response programs. The study also revealed changes in the immune and normal cell landscape, as well as enhanced tumor cell-to-oligodendrocyte interactions in a subset of patients. The findings provide a comprehensive understanding of pHGG and offer potential therapeutic targets. [Extracted from the article] |
