| Abstrakt: |
A recent study conducted by researchers at Charles University explored the therapeutic potential of Sertoli cells (SCs) in alleviating acute inflammation-induced testicular damage. The researchers administered SCs intravenously in a mouse model and found that the cells demonstrated a distinctive migration pattern, concentrating in the testes and liver. The SC treatment significantly reduced neutrophil infiltration and preserved resident macrophage subpopulations. Additionally, the treatment exhibited protective effects on sperm quality, including motility and kinematic parameters, and maintained the physiological testicular morphology. These findings contribute to the expanding knowledge on cell-based therapies for addressing reproductive health challenges and offer a promising approach for targeted interventions in male infertility. [Extracted from the article] |
