Autor: |
Sakamoto, Akimasa, Sakamoto, Katsunori, Hikida, Takahiro, Ito, Chihiro, Iwata, Miku, Shine, Mikiya, Uraoka, Mio, Nishi, Yusuke, Nagaoka, Tomoyuki, Honjo, Masahiko, Tamura, Kei, Funamizu, Naotake, Ogawa, Kohei, Takada, Yasutsugu |
Předmět: |
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Zdroj: |
Surgery Today; Oct2024, Vol. 54 Issue 10, p1193-1200, 8p |
Abstrakt: |
Purpose: Post-transplant biliary stricture (PBS) is a common and important complication following orthotopic liver transplantation (LT). This study clarified the incidence of PBS and identified its risk factors. Methods: We retrospectively reviewed the medical records of 67 patients who underwent living-donor LT (LDLT) at our institute between June 2010 and July 2022 and analyzed their clinical characteristics, prognosis, and risk factors for PBS. Results: Of the 67 patients, 26 (38.8%) developed PBS during the observation period. Multivariate analyses revealed the following independent risk factors for PBS formation: increased red cell transfusion volume per body weight (> 0.2 U/kg; hazard ratio [HR], 3.8; P = 0.002), increased portal vein pressure (PVP) at the end of LT (> 16 mmHg; HR, 2.88; P = 0.032), postoperative biliary leakage (HR, 4.58; P = 0.014), and prolonged warm ischemia time (WIT) (> 48 min; HR, 4.53; P = 0.008). In patients with PBS, the cumulative incidence of becoming stent free was significantly higher in patients with a WIT ≤ 48 min than in those with a WIT > 48 min (P = 0.038). Conclusion: Prolonged WIT is associated with intractable PBS following LDLT. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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